Probiotic with its targeting exosome-like vesicles
Functional Exosome-
like Vesicles
Gut-Brain Axis
Specificity
Fast-acting
ExoBDNF® is a game-changing probiotic for brain health, derived from Pediococcus acidilactici CGPA01. This probiotic not only possesses the well-known benefits of traditional probiotics, but its derived vesicles also reach the hippocampus via the gut-brain axis, promoting an increase in the neurotrophic factor BDNF.
ExoBDNF™ has the ability to produce functional exosome-like vesicles (ExoBDNF-EVs) that mediate brain health.
What is exosome?
Exosomes are cell-derived vesicles, ranging in size from 30 to 150 nm, that carry key molecules such as peptides, nucleic acids, and lipids, potentially modulating intercellular communication.
ExoBDNF® can produce functional exosome-like vesicles (as shown in the image on the left), approximately 100 nm in size, which affect both gut and brain health.
How does it work?
Emerging evidence indicates that the gut microbiota communicates bidirectionally with the brain via the gut-brain axis. Both preclinical and clinical studies support the role of probiotics in modulating neurotransmitters, brain structure, and cognitive function.
When ExoBDNF® reaches the intestines, it releases bioactive exosome-like vesicles (ExoBDNF-EVs). These EVs travel not only through blood circulation to the brain, but also directly via the vagus nerve—yes, through the vagus nerve itself! This dual-route mechanism ensures not only faster delivery but also enhanced transport efficiency and capacity.
As a result, ExoBDNF® effectively and rapidly promotes the expression of brain-derived neurotrophic factor (BDNF) in nerve cells, helping to support optimal brain and cognitive function.
ExoBDNF-EVs reaches the brain through the nervous system (Vagus Nerve) like a truck on a highway, delivering its cargo directly and swiftly to the target. This route not only ensures quick delivery but also allows for transport capacity on a larger scale, thereby enhancing its bioavailability.
Dr. Shih, SunWay R&D Manager
Applications
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The communication is intended for business-to-business information and not for the final consumer. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
